Efficacy on nasal
obstruction of various etiologies
Open study investigating the efficacy
and tolerance of Sinomarin® on patients with various nasal
and/or sinus disorders, resulting in permanent or
80 adult patients receiving Sinomarin® monotherapy for 2
weeks, 3 times per day, 2 applications per nostril.
Significant Improvement in nasal
→ 77,4% of cases
333 patients over 12 years of age. 20 day protocol with 3
visits to physician (Visit #1= Baseline – treatment
initiation; Visit #2 = day 10; Visit #3 = day 20- end of
treatment); 2 investigation groups: 1) Sinomarin® plus
treatment, 2) treatment without Sinomarin® (control
group). Medicinal treatments were dependent on condition.
Results based on Analog Scales (1-12).
Significant Improvement on general
→ 81% of cases
Good or excellent tolerance
→ 95% of
Effective adjunct treatment for
An investigational, prospective, longitudinal,
comparative, multicenter, open-label study on the efficacy
and tolerance of Sinomarin® for the treatment of
Patients using Sinomarin® as
an adjunct treatment demonstrated statistically significant
efficacy versus control group (prescribed treatment alone)
from the second visit onwards, in all parameters evaluated
i.e. nasal obstruction (Fig. 1), level of rhinorrhea (Fig.
2), nasal comfort, tolerance, patient & investigator
Effective on the nasal mucosa
A prospective randomized study investigating the effect of
different irrigation solutions (incl. sea water at 2.3%
NaCl) on mucocilliary activity & nasal patency, on
patients following nasal surgery (septoplasty)22.
45 septoplasty patients; 3 randomly divided investigation
groups receiving: 1) 2.3% buffered hypertonic seawater, 2)
buffered isotonic saline solution, 3) non-buffered isotonic
saline; post-operative administration of irrigation
solutions for 20 days, 6 applications per nostril per day.
Nasal Airway Patency
On 20th postoperative day
Difference from 5th day
(mean ± SD) (cm2)
Difference from 5th day
(mean ± SD) (%)
NAP (2.3% buffered hypertonic saline)
0.37 ± 0.19
62.6 ± 43.4
NAP (2.3% buffered isotonic saline)
0.15 ± 0.20
26.3 ± 38.3
Treatment with 2.3% buffered
hypertonic saline solutions improved nasal patency between
the 5th and 20th post-operative days following septoplasty.
This improvement was superior to the effect observed with
0.9% buffered isotonic solutions in a statistically
significant manner (p = 0.042).
1. Freche C et al., “Usefulness of
hypertonic sea water (Sinomarin®) in rhinology”, Revue
Officielle de la Société Française de ORL, 50(4), 1998.
→ Buffered hypertonic
solutions used following endonasal surgery decrease
inflammation of the nasal mucosa resulting in a significant
decongestive effect. They present superior efficacy to
2. González G et al., “A clinical study conducted in 2007
with Mexican patients: an investigational, prospective,
longitudinal, comparative, multicentre, open-label study
on the efficacy and tolerability of Sinomarin Spray for
the treatment of rhinitis”, Journal of the Federation of
Otalaryngological and Societies of the Mexican Republic (FESORMEX),
22. Süslü N. et al., ‘Effects of buffered 2.3%, buffered
0.9%, and non-buffered 0.9% irrigation solutions on nasal
mucosa after septoplasty”, Eur Arch Otorhinolaryngol