What is Sinomarin
 How does Sinomarin work?
 Nasal irrigation & decongestion
 Indications for using Sinomarin
 When should Sinomarin be used


The benefits of seawater

Nasal irrigation & decongestion

The use of nasal irrigation dates back centuries to yogic and ayurvedic traditions where hypertonic saline solutions were used for nasal irrigation for purification purposes as part of the preparation process. Western medicine has adopted this practice since the 19th century where nasal irrigation has been recommended for the treatment of sinonasal pathology.

Nasal irrigation and thus cleansing -performed using a neti pot (neti in Sanskrit means "nasal cleansing"), nebulizers or most commonly nasal sprays- is being used extensively in modern medicine to flush out dust, debris, pollutants, allergens, germs and excess mucus from the nose and sinuses which can lead to sinonasal blockage and infection.

Whereas nasal irrigation can be carried out using ordinary tap water, this is generally felt to be uncomfortable because it irritates the mucous membranes. Therefore an isotonic or hypertonic salt water solution is normally used.

Medical Conclusions

Below you can find some of the medical conclusions for Hypertonic Seawater. By pressing on the links you may revert to a summary of the publication.

“Hypertonic seawater solution has been proven to be better than isotonic seawater solution in eliminating the symptoms of nasal congestion, rhinorrhea, cough, headache and waking up during the night… in patients with chronic rhinosinusitis”.
Culig J., et al. Efficiency of hypotonic and isotonic sea water solutions in chronic rhinosinusitis. Medicinski Glaskik, Vol.7, No.2 Aug. 2010.

“Nasal rinsing with hypertonic saline solution is a safe and effective treatment option in pregnant women with seasonal allergic rhinitis.”
Garavello W, et al. Nasal lavage in pregnant women with seasonal allergic rhinitis: a randomized study. Int Arch Allergy Immunol. 2010;151(2):137-41. Epub 2009 Sep 15.

“Hypertonic solution irrigation using Sinomarin® (2.3%) is beneficial, since it enables a more rapid action on the edema, a virtually common characteristic of nasal, catarrhal, infectious or allergic disorders.”
González G. JA; Sánchez A. Y ; Mejía R. An investigational, prospective, longitudinal, comparative, multicentre, open-label study on the efficacy and tolerability of Sinomarin Spray for the treatment of rhinitis. Journal of the Federation of Otolaryngological Colleges and Societies of the Mexican Republic, 2008

“Buffered hypertonic seawater improves nasal airway patency more than the buffered isotonic saline. Buffered hypertonic solutions used after endonasal surgery have been advantageous for both mucociliary clearance and postoperative decongestion.”
Süslü N, et. al. Effects of buffered 2.3%, buffered 0.9%, and non-buffered 0.9% irrigation solutions on nasal mucosa after septoplasty. Eur Arch Otorhinolaryngol. 2009 May;266(5):685-9. Epub 2008 Sep 18.

“Patients with frequent rhinosinusitis and daily sinus symptoms, symptoms of concomitant allergic rhinitis, asthma, or polyposis may improve with hypertonic saline nasal irrigation. There is strong evidence that hypertonic saline nasal irrigation is an effective adjunctive treatment for symptoms of chronic rhinosinusitis.”
Rabago D, Guerard E, Bukstein D. Nasal irrigation for chronic sinus symptoms in patients with allergic rhinitis, asthma, and nasal polyposis: a hypothesis generating study. WMJ. 2008 Apr;107(2):69-75.

“Hypertonic saline decreases the nasal edema and influences the mucocilliary function through the fluid secretion in vitro.”
Li HB, et. al. . Hypertonic saline solution stimulated CLC-3 production in primary cultured human nasal epithelial cells. Auris Nasus Larynx. 2008 Mar;35(1):47-51.

“Nasal irrigation using Hypertonic Sea Water Solution is recommended for chronic rhinosinusitis. The ENT professions suggest the use of hypertonic seawater solution better that hypertonic saline, while hypertonic solutions give far better results than isotonic saline.”
W.J. Fokkens, V.J. Lund, J. Mullol et al., European Position Paper on Nasal Polyps 2007.
Rhinology 45; suppl. 20: 1-139.

“Nebulized 3% hypertonic saline (HS) is superior to normal saline; effective treatment for infants hospitalized with moderately severe viral bronchiolitis”
Kuzik BAet. al. Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants. J Pediatr. 2007 Sep;151(3):266-70, 270.e1. Epub 2007 Jun 29.
Zhang L, et. al., Nebulized hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006458.

“Superiority of Dead Sea Salt over saline nasal irrigation for treatment of chronic rhinosinusitis”.
Friedman M, Vidyasagar R, Joseph N. A randomized, prospective, double-blind study on the efficacy of dead sea salt nasal irrigations. Laryngoscope. 2006 Jun;116(6):878-82.

“Hypertonic saline nasal irrigation is a safe, well-tolerated, inexpensive, effective, long-term therapy that patients with chronic sinonasal symptoms”.
Rabago D, et. al. Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study. Ann Fam Med. 2006 Jul-Aug;4(4):295-301.

“Participants with chronic sinonasal symptoms reported improved quality-of-life and frequent, satisfying use of hypertonic saline nasal irrigation.”
Rabago D, et. al. The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol Head Neck Surg. 2005 Jul;133(1):3-8.

“The administration of hypertonic saline results in a significantly faster ciliary beat frequency 5 minutes after administration”
Wabnitz DA, Wormald PJ. A blinded, randomized, controlled study on the effect of buffered 0.9% and 3% sodium chloride intranasal sprays on ciliary beat frequency. Laryngoscope. 2005 May;115(5):803-5.

“Buffered hypertonic saline affected saccharine clearance times (i.e. mucocialiary clearance) to a greater degree than buffered normal saline.”
Keojampa BK, Nguyen MH, Ryan MW. Effects of buffered saline solution on nasal mucociliary clearance and nasal airway patency. Otolaryngol Head Neck Surg. 2004 Nov;131(5):679-82.

“When nasal irrigations are combined with other medical modalities, patients with chronic sinusitis may not require surgical intervention as often …patients using hypertonic saline nasal irrigations reported better outcomes.”
Brown CL and Graham SM., “Nasal irrigations: good or bad?” Current Opinion in Otolarynology & Head and Neck Surgery 12:9-13,2004.

“Nasal lavage with hypertonic saline is a useful adjunctive treatment in the management of pediatric seasonal allergic rhinoconjuctivitis” 
Garavello W, et al. Nasal rinsing with hypertonic solution: an adjunctive treatment for pediatric seasonal allergic rhinoconjunctivitis. Int Arch Allergy Immunol. 2005 Aug;137(4):310-4. Epub 2005 Jun 20. 
Garavello W, et al. Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: a randomized study. Pediatr Allergy Immunol. 2003 Apr;14(2):140-3.

“Hypertonic saline alone evokes mucinous secretion in human nasal airways in vivo” 
Greiff L, Andersson M, Wollmer P, Persson CG. Hypertonic saline increases secretory and exudative responsiveness of human nasal airway in vivo. Eur Respir J. 2003 Feb;21(2):308-12.

“Daily hypertonic saline nasal irrigation improves sinus-related quality-of-life, decreases symptoms, and decreases medication use in patients with frequent sinusitis.” 
Rabago D et al., “Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: A randomised controlled trial”. J. Fam. Pract. 51:1049-1055, 2002.

“Hypertonic saline solutions improve mucociliary clearance.” 
Homer JJ, Dowley AC, Condon L, El-Jassar P, Sood S. The effect of hypertonicity on nasal mucociliary clearance. Clin Otolaryngol Allied Sci. 2000 Dec;25(6):558-60.

“Nasal irrigation [with hypertonic saline] is effective in improving symptoms and the health status of patients with sinonasal disease” 
Tomooka LT et al., “Clinical study and literature review of nasal irrigation”. Laryngoscope. 110(7):1189-93, 2000.

“Nasal hypertonic saline irrigation in children <5years improved symptoms of nasal problems with decrease or disappearance of pathogenic bacteria after the two weeks of treatment without the use of antibiotics” 
Mihoko I. et. al. The effectiveness of nasal irrigation in the treatment of infant nasal problems. Japanese Journal of Rhinology 38 (2):230-234, 1999.

“Use of hypertonic seawater (2.3%) is effective on nasal obstruction (hypertrophic rhinitis, allergic rhinitis, polyposis, vasomotor rhinitis, purulent rhinitis, unspecified rhinitis”
Freche et al., “Usefulness of hypertonic seawater (Sinomarin®) in rhinology. Revue Officielle de la Societe Francaise de ORL, 50(4), 1998.

“Hypertonic saline nasal wash is an efficient treatment of chronic sinusitis.” 
Shoseyov D et al., “Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis. J. Allergy Clin. Immunol. 101:602-5, 1998.

"Buffered hypertonic saline nasal irrigation improves mucociliary transit times of saccharin, while buffered normal saline had no such effect. Hypertonic saline is thus superior to buffered normal saline for mucociliary clearance" 
Talbot AR et al., “Mucociliary clearance and buffered hypertonic saline solution”. Laryngoscope 107(4):500-3, 1997.

European Positioning Paper